Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/181065
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dc.contributor.authorLin, Yu-Chienen_US
dc.contributor.authorLee, Chin-Yunen_US
dc.contributor.authorJones, Julian R.en_US
dc.contributor.authorLiu, Wai-Chingen_US
dc.contributor.authorCho, Nam-Joonen_US
dc.contributor.authorHu, Chih-Chienen_US
dc.contributor.authorChung, Ren-Jeien_US
dc.date.accessioned2024-11-13T01:47:10Z-
dc.date.available2024-11-13T01:47:10Z-
dc.date.issued2024-
dc.identifier.citationLin, Y., Lee, C., Jones, J. R., Liu, W., Cho, N., Hu, C. & Chung, R. (2024). Sustained antibiotic release from biodegradable gelatin–silica hybrid for orthopedic infections. Advanced Functional Materials, 2409491-. https://dx.doi.org/10.1002/adfm.202409491en_US
dc.identifier.issn1616-301Xen_US
dc.identifier.urihttps://hdl.handle.net/10356/181065-
dc.description.abstractAntibiotic-loaded polymethylmethacrylate (PMMA) beads are commonly employed to treat prosthetic joint infections (PJI) and chronic osteomyelitis due to their excellent mechanical strength. However, PMMA's non-degradability results in a burst release of antibiotics and potential renal toxicity, necessitating additional surgeries for bead removal. There is a critical need for infection control materials that can deliver antibiotics effectively, maintain adequate mechanical strength, and degrade uniformly. This study introduces a gelatin–silica hybrid antibiotic carrier, characterized by covalent bonds between the gelatin and silica networks. The incorporation of the silica network enhances the compressive strength to 32.53 ± 2.4 MPa and ensures uniform degradation over 6 months, aligning with clinical timelines. Furthermore, the gelatin–silica hybrid can support up to 10 wt% antibiotic loading without compromising its properties, making it a promising candidate for next-generation infection control materials.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relationMOET32022-0008en_US
dc.relation.ispartofAdvanced Functional Materialsen_US
dc.rights© 2024 Wiley-VCH GmbH. All rights reserved.en_US
dc.subjectEngineeringen_US
dc.titleSustained antibiotic release from biodegradable gelatin–silica hybrid for orthopedic infectionsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.researchCentre for Cross Economyen_US
dc.identifier.doi10.1002/adfm.202409491-
dc.identifier.scopus2-s2.0-85202470276-
dc.identifier.spage2409491en_US
dc.subject.keywordsAntibacterial activityen_US
dc.subject.keywordsBiodegradableen_US
dc.description.acknowledgementThe authors are grateful for the financial support received from the National Science and Technology Council of Taiwan (NSTC 111-2622-E-027-022; NSTC 112-2622-E-027-020; NSTC 112-2314-B-182A-102-MY2). In addition, this work was financially supported by the Tier 3 program (grant no. MOET32022-0008).en_US
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