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https://hdl.handle.net/10356/181065
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lin, Yu-Chien | en_US |
dc.contributor.author | Lee, Chin-Yun | en_US |
dc.contributor.author | Jones, Julian R. | en_US |
dc.contributor.author | Liu, Wai-Ching | en_US |
dc.contributor.author | Cho, Nam-Joon | en_US |
dc.contributor.author | Hu, Chih-Chien | en_US |
dc.contributor.author | Chung, Ren-Jei | en_US |
dc.date.accessioned | 2024-11-13T01:47:10Z | - |
dc.date.available | 2024-11-13T01:47:10Z | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | Lin, Y., Lee, C., Jones, J. R., Liu, W., Cho, N., Hu, C. & Chung, R. (2024). Sustained antibiotic release from biodegradable gelatin–silica hybrid for orthopedic infections. Advanced Functional Materials, 2409491-. https://dx.doi.org/10.1002/adfm.202409491 | en_US |
dc.identifier.issn | 1616-301X | en_US |
dc.identifier.uri | https://hdl.handle.net/10356/181065 | - |
dc.description.abstract | Antibiotic-loaded polymethylmethacrylate (PMMA) beads are commonly employed to treat prosthetic joint infections (PJI) and chronic osteomyelitis due to their excellent mechanical strength. However, PMMA's non-degradability results in a burst release of antibiotics and potential renal toxicity, necessitating additional surgeries for bead removal. There is a critical need for infection control materials that can deliver antibiotics effectively, maintain adequate mechanical strength, and degrade uniformly. This study introduces a gelatin–silica hybrid antibiotic carrier, characterized by covalent bonds between the gelatin and silica networks. The incorporation of the silica network enhances the compressive strength to 32.53 ± 2.4 MPa and ensures uniform degradation over 6 months, aligning with clinical timelines. Furthermore, the gelatin–silica hybrid can support up to 10 wt% antibiotic loading without compromising its properties, making it a promising candidate for next-generation infection control materials. | en_US |
dc.description.sponsorship | Ministry of Education (MOE) | en_US |
dc.language.iso | en | en_US |
dc.relation | MOET32022-0008 | en_US |
dc.relation.ispartof | Advanced Functional Materials | en_US |
dc.rights | © 2024 Wiley-VCH GmbH. All rights reserved. | en_US |
dc.subject | Engineering | en_US |
dc.title | Sustained antibiotic release from biodegradable gelatin–silica hybrid for orthopedic infections | en_US |
dc.type | Journal Article | en |
dc.contributor.school | School of Materials Science and Engineering | en_US |
dc.contributor.research | Centre for Cross Economy | en_US |
dc.identifier.doi | 10.1002/adfm.202409491 | - |
dc.identifier.scopus | 2-s2.0-85202470276 | - |
dc.identifier.spage | 2409491 | en_US |
dc.subject.keywords | Antibacterial activity | en_US |
dc.subject.keywords | Biodegradable | en_US |
dc.description.acknowledgement | The authors are grateful for the financial support received from the National Science and Technology Council of Taiwan (NSTC 111-2622-E-027-022; NSTC 112-2622-E-027-020; NSTC 112-2314-B-182A-102-MY2). In addition, this work was financially supported by the Tier 3 program (grant no. MOET32022-0008). | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
Appears in Collections: | MSE Journal Articles |
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