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DC Field | Value | Language |
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dc.contributor.author | Poh, Xuan Ying | en_US |
dc.contributor.author | Lee, I. Russel | en_US |
dc.contributor.author | Tan, Chee Wah | en_US |
dc.contributor.author | Chavatte, Jean-Marc | en_US |
dc.contributor.author | Fong, Siew Wai | en_US |
dc.contributor.author | Goh, Yun Shan | en_US |
dc.contributor.author | Rouers, Angeline | en_US |
dc.contributor.author | Wong, Nathan | en_US |
dc.contributor.author | Torres-Ruesta, Anthony | en_US |
dc.contributor.author | Mah, Shirley Y. Y. | en_US |
dc.contributor.author | Yeoh, Aileen Y. Y. | en_US |
dc.contributor.author | Gandhi, Mihir | en_US |
dc.contributor.author | Rahman, Nabilah | en_US |
dc.contributor.author | Chin, Yi Qing | en_US |
dc.contributor.author | Lim, J Jonathan | en_US |
dc.contributor.author | Yoong, Terence J. K. | en_US |
dc.contributor.author | Rao, Suma | en_US |
dc.contributor.author | Chia, Po Ying | en_US |
dc.contributor.author | Ong, Sean W. X. | en_US |
dc.contributor.author | Lee, Tau Hong | en_US |
dc.contributor.author | Sadarangani, Sapna P. | en_US |
dc.contributor.author | Lin, Ray J. H. | en_US |
dc.contributor.author | Lim, Daniel R. X. | en_US |
dc.contributor.author | Chia, Wanni | en_US |
dc.contributor.author | Renia, Laurent | en_US |
dc.contributor.author | Ren, Ee Chee | en_US |
dc.contributor.author | Lin, Raymond T. P. | en_US |
dc.contributor.author | Lye, David C. | en_US |
dc.contributor.author | Wang, Lin-Fa | en_US |
dc.contributor.author | Ng, Lisa F. P. | en_US |
dc.contributor.author | Young, Barnaby Edward | en_US |
dc.date.accessioned | 2024-12-02T05:15:34Z | - |
dc.date.available | 2024-12-02T05:15:34Z | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | Poh, X. Y., Lee, I. R., Tan, C. W., Chavatte, J., Fong, S. W., Goh, Y. S., Rouers, A., Wong, N., Torres-Ruesta, A., Mah, S. Y. Y., Yeoh, A. Y. Y., Gandhi, M., Rahman, N., Chin, Y. Q., Lim, J. J., Yoong, T. J. K., Rao, S., Chia, P. Y., Ong, S. W. X., ...Young, B. E. (2024). First SARS-CoV-2 Omicron infection as an effective immune booster among mRNA vaccinated individuals: final results from the first phase of the PRIBIVAC randomised clinical trial. EBioMedicine, 107, 105275-. https://dx.doi.org/10.1016/j.ebiom.2024.105275 | en_US |
dc.identifier.issn | 2352-3964 | en_US |
dc.identifier.uri | https://hdl.handle.net/10356/181427 | - |
dc.description.abstract | Background: Understanding how SARS-CoV-2 breakthrough infections impacts the breadth of immune responses against existing and pre-emergent SARS-CoV-2 strains is needed to develop an evidence-based long-term immunisation strategy. Methods: We performed a randomised, controlled trial to assess the immunogenicity of homologous (BNT162b2) versus heterologous (mRNA-1273) booster vaccination in 100 BNT162b2-vaccinated infection-naïve individuals enrolled from October 2021. Post hoc analysis was performed to assess the impact of SARS-CoV-2 infection on humoral and cellular immune responses against wild-type SARS-CoV-2 and/or Omicron subvariants. Findings: 93 participants completed the study at day 360. 71% (66/93) of participants reported first SARS-CoV-2 Omicron infection by the end of the study with similar proportions of infections between homologous and heterologous booster groups (72.3% [34/47] vs 69.6% [32/46]; p = 0.82). Mean wildtype SARS-CoV-2 anti-S-RBD antibody level was significantly higher in heterologous booster group compared with homologous group at day 180 (14,588 IU/mL; 95% CI, 10,186–20,893 vs 7447 IU/mL; 4646–11,912; p = 0.025). Participants who experienced breakthrough infections during the Omicron BA.1/2 wave had significantly higher anti-S-RBD antibody levels against wildtype SARS-CoV-2 and antibody neutralisation against BA.1 and pre-emergent BA.5 compared with infection-naïve participants. Regardless of hybrid immunity status, wildtype SARS-CoV-2 anti-S-RBD antibody level declined significantly after six months post-booster or post-SARS-CoV-2 infection. Interpretation: Booster vaccination with mRNA-1273 was associated with significantly higher antibody levels compared with BNT162b2. Antibody responses are narrower and decline faster among uninfected, vaccinated individuals. Boosters may be more effective if administered shortly before infection outbreaks and at least six months after last infection or booster. | en_US |
dc.description.sponsorship | Agency for Science, Technology and Research (A*STAR) | en_US |
dc.description.sponsorship | Ministry of Education (MOE) | en_US |
dc.description.sponsorship | National Medical Research Council (NMRC) | en_US |
dc.language.iso | en | en_US |
dc.relation | STPRG-FY19-001 | en_US |
dc.relation | COVID19RF-003 | en_US |
dc.relation | COVID19RF-011 | en_US |
dc.relation | COVID19RF-018 | en_US |
dc.relation | COVID19RF-060 | en_US |
dc.relation | OFLCG19May-0034 | en_US |
dc.relation | ACCL/19-GAP064-R20H-H | en_US |
dc.relation | H/20/04/g1/006 | en_US |
dc.relation | SUJ #022388-00001 | en_US |
dc.relation | CSAINV22jul-0015 | en_US |
dc.relation.ispartof | EBioMedicine | en_US |
dc.rights | © 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.subject | Medicine, Health and Life Sciences | en_US |
dc.title | First SARS-CoV-2 Omicron infection as an effective immune booster among mRNA vaccinated individuals: final results from the first phase of the PRIBIVAC randomised clinical trial | en_US |
dc.type | Journal Article | en |
dc.contributor.school | Lee Kong Chian School of Medicine (LKCMedicine) | en_US |
dc.contributor.school | School of Biological Sciences | en_US |
dc.contributor.organization | National Centre for Infectious Diseases, Singapore | en_US |
dc.contributor.organization | Tan Tock Seng Hospital | en_US |
dc.contributor.organization | A*STAR Infectious Diseases Labs | en_US |
dc.contributor.organization | Yong Loo Lin School of Medicine, NUS | en_US |
dc.identifier.doi | 10.1016/j.ebiom.2024.105275 | - |
dc.description.version | Published version | en_US |
dc.identifier.pmid | 39137572 | - |
dc.identifier.scopus | 2-s2.0-85200952064 | - |
dc.identifier.volume | 107 | en_US |
dc.identifier.spage | 105275 | en_US |
dc.subject.keywords | Cellular response | en_US |
dc.subject.keywords | COVID-19 booster | en_US |
dc.description.acknowledgement | The study is supported in part by grants from Singapore’s National Medical Research Council (NMRC) [STPRG-FY19-001, COVID19RF-003, COVID19RF-011, COVID19RF-018, COVID19RF-060 and OFLCG19May-0034], the Biomedical Research Council, A*CRUSE (Vaccine monitoring project), A*ccelerate GAP-funded project (ACCL/19-GAP064-R20H-H) from Agency for Science, Technology and Research (A*STAR), A*STAR COVID-19 Research funding (H/20/04/g1/006), A*STAR Career Development Fund to YS Goh (SC35/22- 805100), U.S. Food and Drug Administration (#75F40120C00085) and by a Start-up University Grant from the Singapore Ministry of Education to L Renia (SUJ #022388-00001). BY is also supported by NMRC via CSAINV22jul-0015. | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
Appears in Collections: | LKCMedicine Journal Articles |
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PIIS2352396424003116.pdf | 2.18 MB | Adobe PDF | ![]() View/Open |
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