Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/181897
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dc.contributor.authorBillaud, Charly Hugo Alexandreen_US
dc.contributor.authorWood, Amanda G.en_US
dc.contributor.authorGriffiths-King, Danielen_US
dc.contributor.authorKessler, Klausen_US
dc.contributor.authorWassmer, Evangelineen_US
dc.contributor.authorFoley, Elaineen_US
dc.contributor.authorWright, Sukhvir K.en_US
dc.date.accessioned2024-12-30T02:23:05Z-
dc.date.available2024-12-30T02:23:05Z-
dc.date.issued2024-
dc.identifier.citationBillaud, C. H. A., Wood, A. G., Griffiths-King, D., Kessler, K., Wassmer, E., Foley, E. & Wright, S. K. (2024). Examining cognition and brain networks using magnetoencephalography in paediatric autoimmune encephalitis and acute disseminated encephalomyelitis: a preliminary study. Brain Communications, 6(4), e248-. https://dx.doi.org/10.1093/braincomms/fcae248en_US
dc.identifier.issn2632-1297en_US
dc.identifier.urihttps://hdl.handle.net/10356/181897-
dc.description.abstractPaediatric autoimmune encephalitis, including acute disseminated encephalomyelitis, are inflammatory brain diseases presenting with cognitive deficits, psychiatric symptoms, seizures, MRI and EEG abnormalities. Despite improvements in disease recognition and early immunotherapy, long-term outcomes in paediatric autoimmune encephalitis remain poor. Our aim was to understand functional connectivity changes that could be associated with negative developmental outcomes across different types of paediatric autoimmune encephalitis using magnetoencephalography. Participants were children diagnosed with paediatric autoimmune encephalitis at least 18 months before testing and typically developing children. All completed magnetoencephalography recording at rest, T1 MRI scans and neuropsychology testing. Brain connectivity (specifically in delta and theta) was estimated with amplitude envelope correlation, and network efficiency was measured using graph measures (global efficiency, local efficiency and modularity). Twelve children with paediatric autoimmune encephalitis (11.2 ± 3.5 years, interquartile range 9 years; 5M:7F) and 12 typically developing controls (10.6 ± 3.2 years, interquartile range 7 years; 8M:4F) participated. Children with paediatric autoimmune encephalitis did not differ from controls in working memory (t(21) = 1.449; P = 0.162; d = 0.605) but had significantly lower processing speed (t(21) = 2.463; P = 0.023; Cohen's d = 1.028). Groups did not differ in theta network topology measures. The paediatric autoimmune encephalitis group had a significantly lower delta local efficiency across all thresholds tested (d = -1.60 at network threshold 14%). Theta modularity was associated with lower working memory (β = -0.781; t(8) = -2.588, P = 0.032); this effect did not survive correction for multiple comparisons (P(corr) = 0.224). Magnetoencephalography was able to capture specific network alterations in paediatric autoimmune encephalitis patients. This preliminary study demonstrates that magnetoencephalography is an appropriate tool for assessing children with paediatric autoimmune encephalitis and could be associated with cognitive outcomes.en_US
dc.language.isoenen_US
dc.relation.ispartofBrain Communicationsen_US
dc.rights© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectSocial Sciencesen_US
dc.titleExamining cognition and brain networks using magnetoencephalography in paediatric autoimmune encephalitis and acute disseminated encephalomyelitis: a preliminary studyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Social Sciencesen_US
dc.identifier.doi10.1093/braincomms/fcae248-
dc.description.versionPublished versionen_US
dc.identifier.pmid39130516-
dc.identifier.scopus2-s2.0-85201052914-
dc.identifier.issue4en_US
dc.identifier.volume6en_US
dc.identifier.spagee248en_US
dc.subject.keywordsAcute disseminated encephalomyelitisen_US
dc.subject.keywordsAutoimmune encephalitisen_US
dc.description.acknowledgementThe current study was supported by a European Research Council-Consolidator Grant (ERC-CoG) to A.G.W. (682734) and internal grant funding from the Aston Institute of Health and Neurodevelopment, Aston University to A.G.W. and D.G.-K. D.G.-K. was funded by a Birmingham Women’s and Children’s Hospital Charity Research Fund Grant (BWCHRF572, 37-6-094) to A.G.W., S.K.W. and E.W. C.B. was funded by a Silver Jubilee PhD studentship from the Encephalitis Society (now Encephalitis International) to A.G.W. and S.K.W. S.K.W. was supported by a Wellcome Trust Fellowship (216613/Z/19/Z).en_US
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