Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/181905
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHui, Si Jianen_US
dc.contributor.authorKumar, Nareshen_US
dc.contributor.authorTan, Cherie Lin Huien_US
dc.contributor.authorChua, Eugene Khye Ginen_US
dc.contributor.authorHallinan, James Thomas Patrick Decourcyen_US
dc.contributor.authorChan, Yiong Huaken_US
dc.contributor.authorSree, Karunaen_US
dc.contributor.authorTan, Jiong Haoen_US
dc.date.accessioned2024-12-30T06:27:17Z-
dc.date.available2024-12-30T06:27:17Z-
dc.date.issued2024-
dc.identifier.citationHui, S. J., Kumar, N., Tan, C. L. H., Chua, E. K. G., Hallinan, J. T. P. D., Chan, Y. H., Sree, K. & Tan, J. H. (2024). AB078. Patterns of treatment delay in patients with symptomatic metastatic epidural spinal cord compression. Chinese Clinical Oncology, 13(Suppl 1), ab078-. https://dx.doi.org/10.21037/cco-24-ab078en_US
dc.identifier.issn2304-3865en_US
dc.identifier.urihttps://hdl.handle.net/10356/181905-
dc.description.abstractBackground: Delayed treatment in symptomatic metastatic epidural spinal cord compression (MESCC) is significantly associated with poorer functional outcomes. In this study, we aim to identify the patterns of treatment delay in patients and factors predictive of postoperative ambulatory function. Methods: Retrospective review of patients with symptomatic MESCC treated surgically between January 2015 and January 2022. MESCC symptoms were categorized into symptoms suggesting cord compression requiring immediate referral and symptoms suggestive of spinal metastases. Multivariate analysis was performed to identify factors predictive of postoperative ambulatory function. Delays in treatment were identified and categorized into patient delay (onset of symptoms till initial medical consultation), diagnostic delay (medical consultation till radiological diagnosis of MESCC), referral delay (from diagnosis till spine surgeon review) and surgical delay (from spine surgeon review till surgery) and compared between patients. Results: One hundred and seventy-eight patients were identified. In this cohort 92 (52.0%) patients were able to ambulate independently, and 86 (48.3%) patients were non independent. One hundred and thirty-nine (78.1%) of patients had symptoms of cord compression and 93 (52.3%) had neurological deficits on presentation. On multivariate analysis, pre-operative neurological deficits (P=0.01) and symptoms of cord compression (P=0.01) were significantly associated with post-operative ambulatory function. Mean total delay was 66 days, patient delay was 41 days, diagnostic delay was 16 days, referral delay was 3 days and surgical delay was 6 days. In patients with neurological deficits, there was a significant decrease in all forms of treatment delay (P<0.05). There was no significant decrease in patient delay, diagnostic delay and referral delay in patients with symptoms of cord compression. Conclusions: Both patients and physicians understand the need for urgent surgical treatment of MESCC with neurological deficits, however there is still a need for increased education and recognition of the symptoms of MESCC.en_US
dc.language.isoenen_US
dc.relation.ispartofChinese Clinical Oncologyen_US
dc.rights© Chinese Clinical Oncology. All rights reserved. This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the noncommercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/ licenses/by-nc-nd/4.0/.en_US
dc.subjectMedicine, Health and Life Sciencesen_US
dc.titleAB078. Patterns of treatment delay in patients with symptomatic metastatic epidural spinal cord compressionen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.21037/cco-24-ab078-
dc.description.versionPublished versionen_US
dc.identifier.issueSuppl 1en_US
dc.identifier.volume13en_US
dc.identifier.spageab078en_US
dc.subject.keywordsMetastatic epidural spinal cord compressionen_US
dc.subject.keywordsTreatment delayen_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:LKCMedicine Journal Articles
Files in This Item:
File Description SizeFormat 
127641-PB2-9047-R3.pdf90.4 kBAdobe PDFThumbnail
View/Open

Page view(s)

37
Updated on Feb 10, 2025

Download(s)

1
Updated on Feb 10, 2025

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.