Dual-hydrogel thermoresponsive system with bioinspired pore control for drug delivery

Abstract

Localized drug delivery systems with controlled release play a crucial role in addressing challenges in introducing therapeutic agents for treatment of diseases. This research article investigates a GelMA-based drug delivery system incorporated with PNIPAM, a LCST (Lower Critical Solution Temperature) polymer. The study characterized the structural changes in the dual-hydrogel thermoresponsive system (known as THERM gel) and showed a 40 % increase in mesh size when THERM gel undergoes phase transition. In comparison, the microporosity of THERM gel showed decrease in pore size at elevated temperature. The opening and closing of pores introduced the controlled release profile of drug model compound. Under the “ON” state, there is a significant release of model compound from THERM gel. The findings highlight the potential of THERM gel as an effective dual-hydrogel system for temperature-triggered drug delivery. The incorporation of PNIPAM introduces a dynamic element to the drug delivery system, enhancing its tunability and controlled release characteristics toward the development of advanced therapeutic delivery systems.