Please use this identifier to cite or link to this item:
Title: Thermodynamic analysis of aging
Authors: Swati Sinha.
Keywords: DRNTU::Engineering::Bioengineering
Issue Date: 2008
Abstract: Aging is the accumulation of changes in an organism. Numerous theories have been proposed to understand mechanism of aging. External environment factors, genomic component, somatic mutation, harmful effects of free radicals, decline of the immune response, deficiency in the endocrine system, accumulation of glycosylation and products, decreasing amount of heat-shock proteins and telomere shortening are thought to be related to aging. In this analysis the changing in the entropy (∆S), which is a measure of the disorder in a system, is evaluated to gain insights into the ageing of the extra-cellular matrix of tail tendons from C57BL6 mice as our animal model. Here, ∆S is modeled by the free expansion of collagen within the extracellular matrix of the tendons (between two age points) for reversible isothermal changes; this yields ∆S as a function of the ratio of fractional cross-sectional areas of collagen. Transmission electron micrographs of C57BL6 mouse tail tendons has been analysed to obtain the fractional cross-sectional area at age groups 1.6, 1.9, 2.6, 4.0, 11.5, 23.0, 29 and 31.5 months; the data was used to determine ∆S from the model. The results revealed that ∆S varies sinusoidally with age. The results obtained have been used to explain the change in entropy due to the collagen fibril assembly during fibrillogenesis.
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:MAE Theses

Files in This Item:
File Description SizeFormat 
  Restricted Access
4.64 MBAdobe PDFView/Open

Page view(s)

Updated on Nov 23, 2020


Updated on Nov 23, 2020

Google ScholarTM


Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.