dc.contributor.authorXue, Renhao
dc.date.accessioned2009-09-09T06:42:17Z
dc.date.accessioned2017-07-23T08:25:24Z
dc.date.available2009-09-09T06:42:17Z
dc.date.available2017-07-23T08:25:24Z
dc.date.copyright2009en_US
dc.date.issued2009
dc.identifier.citationXue, R. H. (2009). Protein kinase C in regulation of exocytosis. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/19009
dc.description.abstractExocytosis, by which secretory vesicles are directed to outer cell membrane and subsequently discharge their contents upon triggering, is an important and ubiquitous cellular process responsible for secretion of neurotransmitters from neurons and hormones from endocrine cells. Exocytosis is highly regulated through the orchestrated actions of various proteins and lipids. It has been well recognized that protein kinase Cs (PKCs) are active regulators of exocytosis via phosphorylating multiple key proteins in the exocytotic cascade. The specific actions mediated by PKCs, however, have not been fully elucidated. The challenges mainly lie in the following aspects: 1) large variety of PKC isoforms and dubious specificity of the commonly used pharmacological tools; 2) large variety of PKC substrates; 4) difficulties to isolate the molecular steps in the highly dynamic exocytotic process.en_US
dc.format.extent165 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Engineering::Chemical engineering::Biotechnologyen_US
dc.titleProtein kinase C in regulation of exocytosisen_US
dc.typeThesis
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.supervisorChen Peng (SCBE)en_US
dc.contributor.supervisorKim Kyong-Tai
dc.description.degreeDOCTOR OF PHILOSOPHY (SCBE)en_US


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