Controlled synthesis of layered double hydroxide compounds with novel morphologies for biological applications

Abstract

The research work presented in this thesis focuses on the synthesis and characterization of drug containing layered double hydroxides (LDHs), a group of anionic clays, with novel properties. Owing to their flexibility in accommodating anionic compounds in their interlayer galleries, they are potential for developing materials with a wide range of applications. In particular, LDH intercalated with organic anions, named as organo-LDH, is one of the most important organic-inorganic hybrid materials that have recently attracted considerable attention in pharmaceutical field. The main research work is to prepare drug-containing LDHs with novel structures and properties. First, we present the work on producing ibuprofen intercalated LDH nanocrystals with different particle size and morphology under different synthesis conditions including solvent type, and aging conditions in chapter 4. As a result, they further affect inter particle interactions that give different aggregation states in the dry powders. It was found that the relatively oriented dense powder through preferential face-to-face and edge-to-edge aggregation of LDH nanoparticels results in a considerably slower release rate of ibuprofen compared with that from the loose ones.