Antibiotic delivery across the blood-brain barrier by nanoparticle system
Liu, Li Hong
Date of Issue2008
School of Materials Science and Engineering
Brain infection, especially bacterial and fungal meningitis, remains to be life-threatening disease despite the existence of numerous clinically available antibiotics. Important challenges include the antimicrobial agent transportation restricted by the blood-brain barrier (BBB) and multi-drug resistance presented by pathogenic microorganisms. The aim of this study is to design multifunctional micelles for brain delivery of antimicrobial agents.