dc.contributor.authorLiew, Kingsley Jiin Liang
dc.date.accessioned2010-01-15T04:04:02Z
dc.date.accessioned2017-07-23T08:42:14Z
dc.date.available2010-01-15T04:04:02Z
dc.date.available2017-07-23T08:42:14Z
dc.date.copyright2010en_US
dc.date.issued2010
dc.identifier.citationLiew, K. J. L. (2010). Global genomics analysis of the rodent malaria parasites Plasmodium Berghei, Plasmodium Chabaudi and Plasmodium Yoelii with emphasis on the identification of novel virulence factors in Plasmodium Yoelii. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/20818
dc.description.abstractThe incompletely sequenced and annotated genomes of the rodent malaria parasite (RMP) species were re-annotated via complementary genomic DNA hybridizations and bioinformatics tools. A common ’core’ set of orthologous Plasmodia genes was then elucidated. Similarly, a RMP specific ortholog gene set was also elucidated. Comparative genomics of different P. yoelii lines confirmed the presence of polymorphic genes under immune selection pressure and revealed potential variant hypothetical genes containing transmembrane domains that may be involved in novel parasite-host interactions. Next, transcriptomic differences between the virulent YM and avirulent YA lines of P. yoelii were determined and genes that are linked to virulence were identified. Two of these genes (PySERA 1 & 2) were further characterized using knockout strategies. While disruption of PySERA1 appears to reduce parasite virulence, there is no apparent effect in the case of disruption of PySERA2, thus suggesting a certain degree of redundancy of this multigene family.en_US
dc.format.extent292 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleGlobal genomics analysis of the rodent malaria parasites Plasmodium Berghei, Plasmodium Chabaudi and Plasmodium Yoelii with emphasis on the identification of novel virulence factors in Plasmodium Yoeliien_US
dc.typeThesis
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorPeter Rainer Preiseren_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en_US


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