Synthesis of natural products by intramolecular Michael addition

Abstract

The intramolecular hetero-Michael addition is one of the most convergent strategies for the synthesis of six membered heterocyclic rings from α,β-unsaturated carbonyl compounds. However, the selection of suitable precursors for the Michael addition so as to provide the efficient stereocontrol is still a challenging issue and seldom reported in the literature. The emphasis of this thesis is placed on the investigation of efficient stereochemistry control in the synthesis of natural products such as (-)-monomorine (I), diospongin A and clavosolide A. The emphasis of this thesis is placed on the investigation of efficient stereochemistry control in the synthesis of natural products such as (-)-monomorine (I), diospongin A and clavosolide A.