Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/2663
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dc.contributor.authorJia, Yiyuen_US
dc.date.accessioned2008-09-17T09:07:20Z
dc.date.available2008-09-17T09:07:20Z
dc.date.copyright2004en_US
dc.date.issued2004
dc.identifier.urihttp://hdl.handle.net/10356/2663
dc.description.abstractIntron phase is a conserved evolutionary character that refers to the location of introns relative to the three nucleotide positions in a triplet codon. In this report, the distribution of intron phase in eukaryotic genes are discussed. Symmetric exons (exons flanked by symmetrical intron phases) are introduced and their statistical significance in the process of eukaryotic gene evolution are discussed. Some novel concepts, such as "mirror exon set", "compact gene", "exon motif", and "impulse" of exon length distribution are introduced. It is found that introns are significantly biased towards phase 0 introns. A pattern showing an excess of symmetric exons ((0,0), (1,1), (2,2)) is also observed. Our proposed new concept about "mirror exon set" further determines that the intron phase distribution is not random. Significant bias of intron phase zero was observed in both "compact" and "extended" protein coding genes as well. These results could provide insights to exon shuffling that is an evolutionary process to create new genes by shuffling exons.en_US
dc.rightsNanyang Technological Universityen_US
dc.subjectDRNTU::Engineering::Computer science and engineering::Computer applications::Life and medical sciences
dc.titleStatistical analysis of intron phase at the splice sites of eukaryotic genesen_US
dc.typeThesisen_US
dc.contributor.supervisorKwoh, Chee Keongen_US
dc.contributor.schoolSchool of Computer Engineeringen_US
dc.description.degreeMaster of Engineering (SCE)en_US
dc.contributor.supervisor2Sakharkar, Meena Kishoreen_US
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