Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/35719
Title: Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products
Authors: Chan, Kok Ping
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
Issue Date: 2007
Source: Chan, K. P. (2007). Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Prins cyclization is one of the most convergent strategies for the synthesis of 2,6-disubstituted tetrahydropyran rings from homoallylic alcohols and aldehydes. However, several limitations, such as the possibility of racemization of the homoallylic alcohol and substrate compatibility, have rendered this methodology a less preferred choice in the total synthesis of natural products containing the THP motifs. The emphasis of this thesis is placed on the evolution of a novel catalytic Prins cyclization to overcome these current limitations, and manifestation of its applicability to the enantioselective synthesis of natural products.
Description: 251 p.
URI: https://hdl.handle.net/10356/35719
DOI: 10.32657/10356/35719
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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