Please use this identifier to cite or link to this item:
|Title:||Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products||Authors:||Chan, Kok Ping||Keywords:||DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis||Issue Date:||2007||Source:||Chan, K. P. (2007). Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products. Doctoral thesis, Nanyang Technological University, Singapore.||Abstract:||Prins cyclization is one of the most convergent strategies for the synthesis of 2,6-disubstituted tetrahydropyran rings from homoallylic alcohols and aldehydes. However, several limitations, such as the possibility of racemization of the homoallylic alcohol and substrate compatibility, have rendered this methodology a less preferred choice in the total synthesis of natural products containing the THP motifs. The emphasis of this thesis is placed on the evolution of a novel catalytic Prins cyclization to overcome these current limitations, and manifestation of its applicability to the enantioselective synthesis of natural products.||Description:||251 p.||URI:||https://hdl.handle.net/10356/35719||DOI:||10.32657/10356/35719||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SPMS Theses|
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.