The role of the 235 kDA protein multigene family (py235) of the malaria parasite plasmodium yoelii in invasion and host cell selection, virulence and immune evasion.
Jayasree Kaveri Iyer.
Date of Issue2007
School of Biological Sciences
A key determinant of lethality in infections by the malaria parasite Plasmodium is the rapid multiplication cycles in the blood of an infected individual. The range of erythrocytes invaded is directly correlated to parasite virulence. The 235kDa protein multigene family (py235) has been previously implicated in mediating host cell selection and invasion in the rodent parasite Plasmodium yoelii. Using P. yoelii, we defined the copy number of py235 genes in parasites exhibiting different virulence.