Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/36028
Title: Effect of external stimuli on cell adhesion dynamics
Authors: Feng, Zhiqin
Keywords: DRNTU::Engineering::Bioengineering
Issue Date: 2006
Source: Feng, Z. Q. (2006). Effect of external stimuli on cell adhesion dynamics. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Adhesion of cells to biomaterials or extracellular matrix (ECM) is a fundamental process in tissue engineering devices and biotechnological process, as well as in organogenesis and tissue maintenance. Anchorage-dependent cells adhering on surface modified with adhesive ligands will spread and undergoes cytoskeleton rearrangement. In turn, the cellular phenotypes of adherent cells on biomaterials are directly correlated with the biophysical responses of cells. However, the lack of integrated bio-analytics for probing the cell-substrate interface poses significant obstacles in the engineering analysis of cells on biomaterial or ECM surface. Based on the principle of confocal reflectance interference contrast microscopy (C-RICM), our group has successfully determined several key biophysical/biomechanical parameters of cells on model ECM. In this thesis, I apply the unique biophysical approaches on the elucidation of the effect of GFP-actin expression, Hepatitis B virus and cytoskeleton-targeting drugs on the biophysical behavior of HepG2 cells on a model ECM.
Description: 210 p.
URI: https://hdl.handle.net/10356/36028
DOI: 10.32657/10356/36028
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Theses

Files in This Item:
File Description SizeFormat 
MAE_THESES_15.pdf25.29 MBAdobe PDFThumbnail
View/Open

Page view(s) 10

318
checked on Oct 27, 2020

Download(s) 10

142
checked on Oct 27, 2020

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.