Identification, analysis and evaluation of human fusion proteins of bacterial origin.
Date of Issue2007
School of Mechanical and Aerospace Engineering
Gene fusion is identified as a common phenomenon in the formation of new proteins. In order to better understand this evolutionary trend, we first designed a methodology for the identification of fusion proteins (the composite proteins) consisting of two or more fusion partners (the component proteins). We then applied the designed methodology to identify human fusion proteins of bacterial origin in the human genome. We thus obtained a comprehensive list of 141 putative human composite proteins consisting of component proteins (or domains) of bacterial origin. The 141 identified human fusion proteins were visually inspected and manually mapped to metabolic pathways using the KEGG pathway database interface. We thus selected six fusion proteins that function as metabolic enzymes in the citric acid cycle.