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https://hdl.handle.net/10356/38626
Title: | Improving detection of chromosomal abnormalities in multiple myeloma using fluorescence in situ hybridization | Authors: | Naw, Wah Wah | Keywords: | DRNTU::Science::Chemistry::Biochemistry::Spectroscopy | Issue Date: | 2010 | Abstract: | Multiple myeloma (MM) cells are hypoproliferative and thus 70% of MM cases are not detected in conventional cytogenetic (CC) that analyses chromosomal abnormality in metaphase cells. In addition, microdeletions such as del13q14 and telomeric translocations such as t(14;16)(q32;q23) are difficult to detect due to the low resolution of G-banding method used in CC. D13S319/LAMP1 and IGH@/MAF, interphase FISH probes for del13q14 and t(14;16)(q32;q23) respectively, are used in this study to detect multiple myeloma cells in bone marrow aspirate of 20 patients. While CC could not detect del13q14 and t(14;16)(q32;q23) in any of the 20 patients, interphase FISH detected these chromosomal abnormalities in half (10/20) of the patients. This study confirms that interphase FISH significantly increases the detection rate of chromosomal abnormalities in multiple myeloma. | URI: | http://hdl.handle.net/10356/38626 | Schools: | School of Biological Sciences | Organisations: | National University Hospital | Rights: | Nanyang Technological University | Fulltext Permission: | restricted | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Student Reports (FYP/IA/PA/PI) |
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