dc.contributor.authorKalpana Palani
dc.date.accessioned2010-05-18T07:13:15Z
dc.date.accessioned2017-07-23T08:43:14Z
dc.date.available2010-05-18T07:13:15Z
dc.date.available2017-07-23T08:43:14Z
dc.date.copyright2010en_US
dc.date.issued2010
dc.identifier.citationKalpana Palani. (2010). Synthetic studies towards bistramide D. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/38774
dc.description.abstractBistramide D is a member of new class of bioactive molecule isolated from the marine ascidian Lissoclinum bistratum in New Caledonia. Bistramides (A, B, C, D and K) show a broad spectrum of biological activity which includes antiproliferative, immunomodulatory, neurotoxic, cytotoxic and antiparasitic properties; the recent studies also show that bistramides bind to Actin. Bistramide A was reported to be very potent for the P388/dox, B16, HT29, and NSCLC-N6 cell lines. Bistramide D has similar activity in the NSCLC-N6 cell line but is comparatively less toxic in vivo. There has been no total synthesis of bistramide D reported till now to our knowledge. These intriguing biological profiles and challenging molecular architecture of bistramides motivated us to synthesize bistramide D.en_US
dc.format.extent199 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Chemistry::Organic chemistry::Organic synthesisen_US
dc.titleSynthetic studies towards bistramide Den_US
dc.typeThesis
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.contributor.supervisorRoderick Wayland Batesen_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SPMS)en_US


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