View Item 
      •   Home
      • 7. Theses and Dissertations
      • Theses and Dissertations
      • View Item
      •   Home
      • 7. Theses and Dissertations
      • Theses and Dissertations
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.
      Subject Lookup

      Browse

      All of DR-NTUCommunities & CollectionsTitlesAuthorsBy DateSubjectsThis CollectionTitlesAuthorsBy DateSubjects

      My Account

      Login

      Statistics

      Most Popular ItemsStatistics by CountryMost Popular Authors

      About DR-NTU

      Thrombogenicity studies on micro/nano topographic surfaces.

      Thumbnail
      View/Open
      KohLiBuay2010.pdf (9.614Mb)
      Author
      Koh, Li Buay.
      Date of Issue
      2010
      School
      School of Materials Science and Engineering
      Abstract
      Platelet adhesion and activation resulting from the interaction between the flowing blood and the surface of foreign material of a medical device or implant are adverse events that lead to the formation of thrombus. The modulation of platelet-surface interactions to increase the thromboresistance of foreign surfaces is therefore a vital aspect in the design of blood-compatible surfaces. In this thesis, the effects of fibrinogen adsorption and subsequent platelet interaction on a variety of surfaces with chemical and topographical structures are investigated. Carbon nanotubes are initially evaluated due to their promising applications in a variety of biological systems. They are employed as means of topographical features to investigate on the influence topographical effect on platelet interaction with surfaces. Additionally, the influence of surface chemistry was also investigated. Specifically, two different types CNT orientations, namely tip-wise and diameter-wise, are incorporated separately within the polymer matrix and compared to that of a pristine graphite surface with similar surface chemistry. The effect of surface chemistry was evaluated by comparing the results from two material surfaces; graphite and a biodegradable polymer. The results highlight that in addition to chemistry, appropriate topographical surface modifications can be a powerful approach to elicit a low level of platelet response.
      Subject
      DRNTU::Engineering
      Type
      Thesis
      Collections
      • Theses and Dissertations

      Show full item record


      NTU Library, Nanyang Avenue, Singapore 639798 © 2011 Nanyang Technological University. All rights reserved.
      DSpace software copyright © 2002-2015  DuraSpace
      Contact Us | Send Feedback
      Share |    
      Theme by 
      Atmire NV
       

       


      NTU Library, Nanyang Avenue, Singapore 639798 © 2011 Nanyang Technological University. All rights reserved.
      DSpace software copyright © 2002-2015  DuraSpace
      Contact Us | Send Feedback
      Share |    
      Theme by 
      Atmire NV
       

       

      DCSIMG