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Title: Catalytic enantioselective addition of nitromethane to imines using bisisoquinoline ligands
Authors: Fang, Xin
Keywords: DRNTU::Engineering::Chemical engineering::Biochemical engineering
Issue Date: 2010
Abstract: The application of bisisoquinolines (BIQ) as catalysts in aza-Henry reactions is relatively new. In this project, bisisoquinoline was prepared from N1, N2-diphenethyloxalamide and polyphosphorous acid. The synthesis process of BIQ was also optimized to give a better yield than literature values. For the aza- Henry reaction, metal salts, solvents used to perform the reaction and different temperatures were optimized. A reaction mechanism was proposed for the reaction based on the experimental findings. HPLC analysis revealed that the enantioselectivity using Boc (tert-butoxyl-carbonyl) protecting group was about 40%. However, better results may be possible with other protecting groups.
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Student Reports (FYP/IA/PA/PI)

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