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Title: Effect of recombinant Wnt protein on the Ex vivo expansion of umbilical cord blood hematopoietic cells.
Authors: Lim, Shy Ni.
Keywords: DRNTU::Science::Biological sciences::Genetics
Issue Date: 2010
Abstract: Wnt gene pathway has shown to play an important role in the maintenance and development of hematopoietic stem cells (HSCs) compartment. The low number of HSCs in each umbilical cord blood (UCB) unit has limited its use in transplantation for adult patients. Therefore, a new method to expand these cells is paramount to extent its use in adult patients. In this study, we explored the effect of recombinant Wnt3a and Wnt5a on the expansion of UCB cells. We found that recombinant Wnt3a and Wnt5a provides viability support, generating a significant expansion of phenotypically and functionally defined progenitors after 11 days. Based on these findings, we might have discovered the novel mechanism of recombinant Wnt3a and Wnt5a in the maintenance and expansion of umbilical cord blood progenitors via viability supporting effect.
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)

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