Receptor mediated adhesion under external stimuli

Abstract

Many studies have shown that Epigallocatechin-3-gallate (EGCG) from green tea, exhibits therapeutic effects that inhibits cancer invasion and metastasis and affects cell proliferation and death Since cell adhesion is an important process that regulates cell migration, the effects of EGCG on cell adhesion is investigated to understand more on its therapeutic effects. This study demonstrated that HepG2 cell cultured with increasing concentration of EGCG results in an increase in rate of adhesion contact area, degree of cell deformation and average adhesion energy of cell. The inhibition of cell migration by EGCG was also observed, which supports the evidence of therapeutic effects from EGCG.