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Title: Yb(OTf)3-catalyzed allenation/ cycloisomerization reaction with propargylic alcohols and amides : a facile synthetic approach to oxazole and its derivatives.
Authors: Teo, Wan Teng.
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
Issue Date: 2010
Abstract: An efficient method for allenation/cycloisomerization reaction of propargylic alcohols with amides in the presence of Yb(OTf)3 (5 mol %) at 100oC to afford oxazoles in moderate to excellent yields is reported herein. The method features ease of starting material preparation, use of a low cost and ecologically benign Lewis acid as catalyst under operationally simplistic conditions.
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Student Reports (FYP/IA/PA/PI)

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