Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/39882
Title: Iron-catalyzed amidation of 1,3-dicarbonyl compounds.
Authors: Ong, Wei Ting.
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
Issue Date: 2010
Abstract: An efficient Fe-catalyzed amidation of 1,3-dicarbonyl compounds to α-amidated products through C(sp3)-H functionalization is achieved via 2 methods; indirect method of using PhI=NTs (Ts = toluene-4-sulfonyl) as nitrogen source and direct method of using PhI(OAc)2 as oxidant and TsNH2 as nitrogen source. The reaction was applied successfully to a variety of aromatic and aliphatic 1,3-dicarbonyl compounds with electron-donating, electron-withdrawing and sterically encumbered groups present in the substrates. The amidated products were obtained in excellent yields up to 99% under mild conditions at room temperature.
URI: http://hdl.handle.net/10356/39882
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Student Reports (FYP/IA/PA/PI)

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