Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/39888
Title: Iron-catalyzed α-amidation of heterocycles with potential route to amino alcohols, amino thiols, and diamino products by nucleophilic ring opening.
Authors: Tania, Stefani.
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
Issue Date: 2010
Abstract: An efficient method for α-amidation of heterocyclic moieties via direct nitrene insertion catalyzed by iron(III)trifluoromethanesulfonate with PhI=NTs (Ts = p-toluenesulfonyl)as a nitrogen source is reported herein. This reaction was shown to be applicable to cyclic ethers, cyclic thioethers, and pyrrolidines to afford the α-amino products in moderate to excellent yields. These amidated compounds were also shown to readily undergo nucleophilic ring opening to give amino alcohols, amino thiols, and diamino products in moderate to excellent yields.
URI: http://hdl.handle.net/10356/39888
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Student Reports (FYP/IA/PA/PI)

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