Sequential michael addition/cyclisation : synthesis of multi-substituted naphthalenes.

Abstract

Naphthalene derivatives have been found in many pharmaceuticals and luminescent materials. Herein, we report a tandem Michael Addition/Cyclisation utilizing aminocatalysis and Lewis acid catalysis to synthesize useful naphthalene derivatives under mild conditions. The Michael addition can work for a range of aldehyes, including aromatic and aliphatic ones.