Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/40103
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suhartono, Timotius Marvin. | - |
dc.date.accessioned | 2010-06-10T05:13:03Z | - |
dc.date.available | 2010-06-10T05:13:03Z | - |
dc.date.copyright | 2010 | en_US |
dc.date.issued | 2010 | - |
dc.identifier.uri | http://hdl.handle.net/10356/40103 | - |
dc.description.abstract | Tumor microenvironment is often characterized with high lactic acid concentration and lactic acid is known to have immunomodulatory effects. In this study, we aim to study the effect of lactic acid on tumor-associated macrophages (TAMs). The TAM phenotype was evaluated in terms of invasion into solid tumor, surface antigen expression, and cytokine secretion profile. To closely mimic the in vivo tumor microenvironment, 3D tumor spheroid model was used, in which monocytes were co-cultured with tumor cells in presence or absence of oxamate, an inhibitor of lactic acid production. We found that lactic acid inhibited monocyte infiltration into tumor spheroid and increased the expression of surface molecules involved in antigen presentation, T cell co-stimulation, and phagocytosis―functions important for antitumor immune response. In addition, lactic acid increased the secretion of pro-inflammatory factors, like IL-6, CXCL10, and G-CSF. These results suggest that lactic acid might promote a pro-inflammatory TAM phenotype with an antitumor potential. | en_US |
dc.format.extent | 38 p. | en_US |
dc.language.iso | en | en_US |
dc.rights | Nanyang Technological University | - |
dc.subject | DRNTU::Science::Biological sciences::Microbiology | en_US |
dc.title | Tumor-derived lactic acid generates a unique macrophage phenotype. | en_US |
dc.type | Final Year Project (FYP) | en_US |
dc.contributor.school | School of Biological Sciences | en_US |
dc.description.degree | Bachelor of Science in Biological Sciences | en_US |
dc.contributor.organization | A*STAR Singapore Immunology Network | en_US |
dc.contributor.supervisor2 | Wong Siew Cheng | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | restricted | - |
Appears in Collections: | SBS Student Reports (FYP/IA/PA/PI) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
SBS09-154.pdf Restricted Access | 13.29 MB | Adobe PDF | View/Open |
Page view(s) 50
597
Updated on Mar 28, 2024
Download(s)
5
Updated on Mar 28, 2024
Google ScholarTM
Check
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.