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Title: Mn(III)-catalyzed synthesis of pyrroles from vinyl azides and B-keto acids.
Authors: Ng, Eileen Pei Jian.
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
Issue Date: 2010
Abstract: β-keto acids and vinyl azides are found to be promising precursors for the synthesis of pyrroles with Mn(acac)3 as a catalyst. One electron oxidation of β-keto acids by Mn(acac)3 induces decarboxylation to afford α-keto radicals, which then add on to vinyl azides, leading to the formation of iminyl radicals with elimination of dinitrogen. Intramolecular cyclization of the iminyl radical with a carbonyl moiety gives pyrrole after dehydration with regeneration of the Mn(III) complex.
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Student Reports (FYP/IA/PA/PI)

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