Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/40602
Title: Fabrication of micro- and nano-particles of drug (I) for pharmaceutical application
Authors: Goh, Boon Beng.
Keywords: DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology
Issue Date: 2010
Abstract: Many drugs are of very poor water solubility, so they tend to be eliminated from the gastrointestinal tract before they could be absorbed into the blood circulation, resulting in low bioavailability and poor dose proportionality. This project aims to improve the solubility of a poorly water-soluble drug known as Quercetin, making micro- and nano-particles (including drug-loaded polymer nano-particles) of it using the evaporative precipitation of nano-suspensions method. Fabrication of the drug particles will be controlled and optimized, and their physicochemical properties will be investigated. For this project, the author has looked into how the choices of solvents and anti-solvents, the concentration of the drug, the solvent to anti-solvent ratio and the presence of the polymer known as Polyvinylpyrrolidone (PVP), will enhance the kinetic solubility and bioavailability of the drug. Characterization of the produced drug were done using the Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Fourier Transform Infra-Red (FT-IR), Dissolution Test and the Ultra-Violet Spectrophotometer.
URI: http://hdl.handle.net/10356/40602
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:MAE Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
m409.pdf
  Restricted Access
5.21 MBAdobe PDFView/Open

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.