Formulation of particles for pulmonary drug delivery
Meer Saiful Hassan
Date of Issue2010
School of Chemical and Biomedical Engineering
Pulmonary drug delivery has become an attractive route of drug administration to the human body for the treatment of lung diseases and a number of systemic applications. Dry powder inhalation (DPI) is considered as the most appropriate aerosol therapeutics in terms of delivery efficiency, patient compliance and environmental issue. Successful delivery of the dry powder formulation to the deep lung requires proper understanding of the factor influencing particle deposition. Improvement of the drug formulation characteristics is the most convenient way to control delivery performance. In this study, the effect of shape and morphology of dry particles for inhalation is investigated. The optimum design of micro-particle for better delivery performance is determined.