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Title: Development of new bio-inspired reactions and application to asymetric total synthesis of antiochic acid
Authors: Zhao, Yu Jun
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
Issue Date: 2008
Source: Zhao, Y. J. (2008). Development of new bio-inspired reactions and application to asymetric total synthesis of antiochic acid. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: To achieve high asymmetric selectivities and high efficiency in biomimetic cationic polyene cyclization is a challenging problem in both academia and industries. The intramolecular acetal-initiated cationic polyene cyclization reaction was first introduced and well developed by W. S. Johnson. However, there exist some disadvantages in this intramolecular polyene cyclization. The need to incorporate the required acetal into the acyclic precursor added synthetic complexity. In addition, the accommodation of the acetal moiety also diminishes the structural flexibility in the acyclic precursor. These two problems, though minor, could reduce the scope and applicability of the method substantially. The emphasis of this thesis is placed on the evolution of a novel intermolecular acetal-initiated polyene cyclization reaction to overcome these current limitations and manifestation of its applicability on the asymmetric total synthesis of natural products.
DOI: 10.32657/10356/41740
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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