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Title: Engineering chondrogenesis with chondroprogenitor/stem cells in gene-transferred co-culture system
Authors: Wang, Don Gan
Keywords: DRNTU::Engineering::Chemical engineering::Biotechnology
Issue Date: 2009
Abstract: Cartilage restoration continues to present a tremendous clinical challenge due to its nonvascular nature. Many studies have demonstrated that chondrogenesis of progenitor cells can be achieved in vitro by manual dose of growth factors; however it remains a vital difficulty in feeding growth factors to implanted therapeutic cells in vivo. The current project aims at cartilage tissue engineering through a co-culture system, in which, genedelivered de-differentiated chondrocytes (The Transfected Companion Cells, TCCs) provide sustained, localized and over-expressed growth factors to mesenchymal stem cells (MSCs) (The Therapeutic Progenitor Cells, TPCs) , and thus induce MSCs to differentiate into chondrocytes.
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Research Reports (Staff & Graduate Students)

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