Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/42433
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dc.contributor.authorLi, Pengen
dc.date.accessioned2010-12-02T05:53:53Zen
dc.date.available2010-12-02T05:53:53Zen
dc.date.copyright2010en
dc.date.issued2010en
dc.identifier.citationLi, P. (2010). Genome design in eukaryotes. Master’s thesis, Nanyang Technological University, Singapore.en
dc.identifier.urihttps://hdl.handle.net/10356/42433en
dc.description.abstractThe availability of complete genome sequences for many eukaryotic organisms continues to contribute towards a better understanding of their genome design and evolution. This investigation involves computational analysis of genome architecture of 6 eukaryotic genomes (4 vertebrate: H.sapiens, P.troglodytes, M.musculus, D.rerio; 2 invertebrate: C.elegans, D.melanogaster). We further analyzed the drug targets, that is, proteins in the human genome with FDA (Food and Drug Administration) approved drugs using various parameters such as protein interacting partners, number of exons, number of pathways, number of tissues and protein family to find if there is any co-relation between these parameters and the targetability of the protein. It was observed that proteins from single exonic genes are more likely to have an FDA approved drug. These data have implications in understanding eukaryotic genome design and may also contribute in drug target selection which is the most important step in drug discovery. Further, a database was constructed on discordant introns. These investigations will help us in understanding eukaryotic genome design.en
dc.format.extent106 p.en
dc.language.isoenen
dc.subjectDRNTU::Science::Biological sciences::Geneticsen
dc.subjectDRNTU::Science::Medicine::Pharmacy::Pharmaceutical technologyen
dc.titleGenome design in eukaryotesen
dc.typeThesisen
dc.contributor.supervisorMeena Sakharkaren
dc.contributor.supervisorZhong Zhaoweien
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen
dc.description.degreeMASTER OF ENGINEERING (MAE)en
dc.identifier.doi10.32657/10356/42433en
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