Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/42458
Title: 2-AZA-[3,3]-Sigmatropic rearrangement and AZA-PRINS cyclization and their applications in total synthesis of (-)-indolizidine-209B and (-)-perhydrohistrionicotoxin
Authors: Cheng, Hin Soon
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
Issue Date: 2010
Source: Cheng, H. S. (2010). 2-AZA-[3,3]-Sigmatropic rearrangement and AZA-PRINS cyclization and their applications in total synthesis of (-)-indolizidine-209B and (-)-perhydrohistrionicotoxin. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Two novel C-C bond formation methodologies, i.e. 2-AZA-[3,3]-sigmatropic rerrangement and aza-Prins cyclization, were developed for the synthesis of linear homoallylic hydroxylamines and 2,3,6-trisubstituted piperidines respectively. These two nitrogen-containing compounds are useful building blocks in many natural products. The applications of these methodologies were then demonstrated in the total syntheses of both (-)-indolizidine 209B and (-)-perhydrohistrionicotoxin.
URI: https://hdl.handle.net/10356/42458
DOI: 10.32657/10356/42458
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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