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https://hdl.handle.net/10356/42735
Title: | Large hollow nanoparticle aggregates as aerosol carrier particles of nanoparticulate drug for dry powder inhaler (DPI) applications : strength of aggregates and particle deposition pattern | Authors: | Kunn, Hadinoto Ong. | Keywords: | DRNTU::Engineering::Chemical engineering::Chemical processes | Issue Date: | 2010 | Abstract: | The emerging trend in the drug discovery process towards identification of poorly-soluble compounds as the lead drug candidates is a consequence of the inherent bias in the high-throughput drug screening method towards lipophilic molecules. Over 40% of the newly discovered drug molecules that are currently in the pharmaceutical pipeline exhibit a poor aqueous solubility that limits their therapeutic efficacy. In addition, approximately 17% of the drug products that are available in the market exhibit a low bioavailability as a result of the poor solubility of their solid dosage form formulation necessitating the use of high and frequent dosings. The systemic bioavailability of poorly-soluble compounds can be greatly enhanced by encapsulating the drug molecules into biocompatible nanoparticulate carriers as a result of the higher dissolution rate. | URI: | http://hdl.handle.net/10356/42735 | Schools: | School of Chemical and Biomedical Engineering | Fulltext Permission: | restricted | Fulltext Availability: | With Fulltext |
Appears in Collections: | SCBE Research Reports (Staff & Graduate Students) |
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Kunn Hadinoto Ong SUG807.pdf Restricted Access | 517.95 kB | Adobe PDF | View/Open |
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