Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/42735
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dc.contributor.authorKunn, Hadinoto Ong.-
dc.date.accessioned2011-01-10T04:26:53Z-
dc.date.available2011-01-10T04:26:53Z-
dc.date.copyright2010en_US
dc.date.issued2010-
dc.identifier.urihttp://hdl.handle.net/10356/42735-
dc.description.abstractThe emerging trend in the drug discovery process towards identification of poorly-soluble compounds as the lead drug candidates is a consequence of the inherent bias in the high-throughput drug screening method towards lipophilic molecules. Over 40% of the newly discovered drug molecules that are currently in the pharmaceutical pipeline exhibit a poor aqueous solubility that limits their therapeutic efficacy. In addition, approximately 17% of the drug products that are available in the market exhibit a low bioavailability as a result of the poor solubility of their solid dosage form formulation necessitating the use of high and frequent dosings. The systemic bioavailability of poorly-soluble compounds can be greatly enhanced by encapsulating the drug molecules into biocompatible nanoparticulate carriers as a result of the higher dissolution rate.en_US
dc.format.extent27 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Engineering::Chemical engineering::Chemical processesen_US
dc.titleLarge hollow nanoparticle aggregates as aerosol carrier particles of nanoparticulate drug for dry powder inhaler (DPI) applications : strength of aggregates and particle deposition patternen_US
dc.typeResearch Report-
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.reportnumberSUG8/07en_US
item.grantfulltextrestricted-
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Appears in Collections:SCBE Research Reports (Staff & Graduate Students)
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