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Title: Large hollow nanoparticle aggregates as aerosol carrier particles of nanoparticulate drug for dry powder inhaler (DPI) applications : strength of aggregates and particle deposition pattern
Authors: Kunn, Hadinoto Ong.
Keywords: DRNTU::Engineering::Chemical engineering::Chemical processes
Issue Date: 2010
Abstract: The emerging trend in the drug discovery process towards identification of poorly-soluble compounds as the lead drug candidates is a consequence of the inherent bias in the high-throughput drug screening method towards lipophilic molecules. Over 40% of the newly discovered drug molecules that are currently in the pharmaceutical pipeline exhibit a poor aqueous solubility that limits their therapeutic efficacy. In addition, approximately 17% of the drug products that are available in the market exhibit a low bioavailability as a result of the poor solubility of their solid dosage form formulation necessitating the use of high and frequent dosings. The systemic bioavailability of poorly-soluble compounds can be greatly enhanced by encapsulating the drug molecules into biocompatible nanoparticulate carriers as a result of the higher dissolution rate.
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Research Reports (Staff & Graduate Students)

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