dc.contributor.authorYuan, Weiyong
dc.identifier.citationYuan, W. Y. (2010). Layer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applications. Doctoral thesis, Nanyang Technological University, Singapore.
dc.description.abstractLayer-by-layer (LbL) self-assembled weak polyelectrolyte-based multilayered films have shown superior tunability and versatility to other polyelectrolyte multilayers. Previous works have focused primarily on the assembly of linearly grown synthetic weak polyelectrolyte multilayers. Further investigation is warranted of weak polyelectrolyte-based self-assembly systems such as natural weak polyelectrolyte multilayers, nanoparticle-participated weak polyelectrolyte multilayers, and exponentially grown multilayers, their unique properties, and novel applications. In particular, in this PhD research project, a chitosan/alginate multilayer film was constructed via LbL self-assembly. The surface composition of the self-assembled multilayer film can be tailored through pH adjustment during the assembly process. The loading capacity of the antibody on the multilayered film and the binding activity of the antigen to the immobilized antibody can be well-tuned by pH control. This work can provide more scientific insight into the interaction between protein and polymer matrix and render a novel, simple approach to build high-performance biointerfaces through pH control for potential applications of highly sensitive immunosensors.en_US
dc.format.extent160 p.en_US
dc.subjectDRNTU::Science::Medicine::Optical instrumentsen_US
dc.titleLayer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applicationsen_US
dc.contributor.researchCentre for Advanced Bionanosystemsen_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.supervisorLi Changmingen_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SCBE)en_US

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