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Title: | Part I Indium-mediated THP ring formation and transformation of halo group into hydroxyl group Part II Palladium-catalyzed direct arylation of cyclic enamides with arylmetallic reagents | Authors: | Zhou, Hai | Keywords: | DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis | Issue Date: | 2011 | Source: | Zhou, H. (2011). Part I: Indium-mediated THP ring formation and transformation of halo group into hydroxyl group. Part II: Palladium-catalyzed direct arylation of cyclic enamides with arylmetallic reagents. Doctoral thesis, Nanyang Technological University, Singapore. | Abstract: | This thesis comprises of two main parts:indium-mediated THP ring formation and functional group transformation, and palladium-catalyzed direct arylation of cyclic enamides with organometallic reagents via C-H functionalization.The thesis includes 5 Chapters. The Chapter 1 is about a one-pot total synthesis of THP-ring natural products. In Chapter 2, the aerobic aqueous transformation of halo group into hydroxyl group via tin-free radical method was presented. In Chapter 3, synthesis of 4,4-dihalotetrahydropyrans via Prins cyclization has been developed. In Chapter 4, Pd(II)-catalyzed direct arylation of cyclic enamides was shown.In chapter 5, the copper-free, palladium-catalyzed Sonogashira cross-coupling reaction was reported. | URI: | https://hdl.handle.net/10356/43519 | DOI: | 10.32657/10356/43519 | Schools: | School of Physical and Mathematical Sciences | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SPMS Theses |
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Tspmsg0503012e.pdf | 2.37 MB | Adobe PDF | View/Open |
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