Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/43519
Title: Part I Indium-mediated THP ring formation and transformation of halo group into hydroxyl group Part II Palladium-catalyzed direct arylation of cyclic enamides with arylmetallic reagents
Authors: Zhou, Hai
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
Issue Date: 2011
Source: Zhou, H. (2011). Part I: Indium-mediated THP ring formation and transformation of halo group into hydroxyl group. Part II: Palladium-catalyzed direct arylation of cyclic enamides with arylmetallic reagents. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: This thesis comprises of two main parts:indium-mediated THP ring formation and functional group transformation, and palladium-catalyzed direct arylation of cyclic enamides with organometallic reagents via C-H functionalization.The thesis includes 5 Chapters. The Chapter 1 is about a one-pot total synthesis of THP-ring natural products. In Chapter 2, the aerobic aqueous transformation of halo group into hydroxyl group via tin-free radical method was presented. In Chapter 3, synthesis of 4,4-dihalotetrahydropyrans via Prins cyclization has been developed. In Chapter 4, Pd(II)-catalyzed direct arylation of cyclic enamides was shown.In chapter 5, the copper-free, palladium-catalyzed Sonogashira cross-coupling reaction was reported.
URI: https://hdl.handle.net/10356/43519
DOI: 10.32657/10356/43519
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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