dc.contributor.authorQi, Yaning
dc.date.accessioned2011-06-02T07:30:43Z
dc.date.accessioned2017-07-23T08:42:20Z
dc.date.available2011-06-02T07:30:43Z
dc.date.available2017-07-23T08:42:20Z
dc.date.copyright2011en_US
dc.date.issued2011
dc.identifier.citationQi, Y. N. (2011). Functional analysis of GGDEF-EAL didomain-containing proteins in cyclic-di-GMP signaling. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/44595
dc.description.abstractCylic-di-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates twitching motility, virulence secretion, cell surface adhesion and biofilm formation. The intracellular concentrations of c-di-GMP are regulated by various GGDEF/EAL domain-containing proteins. My PhD study utilized biochemical and biophysical approaches to probe the function and mechanism of three representative GGDEF-EAL didomain-containing proteins, including PA2567, FimX from Pseudomonas aeruginosa and AxDGC2 from Acetobacter xylinum. The detailed elucidation of catalytic and regulatory mechanism of the three proteins yielded insights into the molecular mechanism of the c-di-GMP signaling network.en_US
dc.format.extent156 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Biological sciences::Biochemistryen_US
dc.titleFunctional analysis of GGDEF-EAL didomain-containing proteins in cyclic-di-GMP signalingen_US
dc.typeThesis
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorLiang Zhao-Xunen_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en_US
dc.identifier.doihttps://doi.org/10.32657/10356/44595


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