Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/44640
Title: Diverse roles of angiopoietin-like 4 : a literature review.
Authors: Chin, Alison Hwee Fang.
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2011
Abstract: Angiopoietin-like (ANGPTL) proteins are a protein family structurally alike to angiopoietins, possessing analogous N-terminal coiled-coil and C-terminal fibrinogen-like domains (FLDs). Despite this, ANGPTLs are considered orphan ligands as they do not bind to angiopoietin receptors, and a specific ANGPTL receptor has yet to be identified. An ANGPTL of particular interest is ANGPTL4, having demonstrated effects in lipid and glucose metabolism, angiogenesis and cancer. Although investigations regarding ANGPTL4 have intensified in recent years, details regarding the role it plays in these processes remain largely unclear. This review aims to provide an overview of existing knowledge regarding ANGPTL4, providing possible directions for further studies based on current understanding of the protein’s roles and mechanisms. With abilities to impact vital biological processes, it is becoming increasingly clear that ANGPTL4 is a protein worthy of continued research. As more knowledge is unearthed, a potential therapeutic role for ANGPTL4 can be determined and refined.
URI: http://hdl.handle.net/10356/44640
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
bs10193.pdf
  Restricted Access
770.25 kBAdobe PDFView/Open

Page view(s) 50

241
checked on Oct 26, 2020

Download(s) 50

13
checked on Oct 26, 2020

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.