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Title: Nanoparticle-mediated photodynamic therapy (PDT) for enhanced anti-tumor effect
Authors: Li, Yunsha.
Keywords: DRNTU::Science::Medicine::Tissue engineering
Issue Date: 2011
Abstract: Photodynamic therapy (PDT) is a medical treatment that utilizes light and photosensitizers to treat a variety of diseases. However, due to tumor drug resistance, cancer cells utilize multiple mechanisms to prevent the accumulation of anti-cancer drugs at their intracellular site of action. In this project, Fe3O4@SiO2@SiO2 nanorattles combined with photodynamic therapy (PDT) using methylene blue (MB) was designed to investigate its anti-cancer efficiency in vitro. Positively charged MB was loaded onto negatively charged Fe3O4@SiO2@SiO2 nanorattles through electrostatic interactions, and the results showed that the MB-loaded Fe3O4@SiO2@SiO2 nanorattles exhibited greater phototoxicity than free MB due to the increased cell uptake of anti-cancer drug delivery vehicles. Moreover, for controlled release investigation, the release profile indicated that the interaction between MB and Fe3O4@SiO2@SiO2 nanorattles was weakened in acidic environments. Based on these findings, it is proposed that PDT mediated by Fe3O4@SiO2@SiO2 nanorattles has potential for enhanced anti-tumor effect.
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Student Reports (FYP/IA/PA/PI)

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