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Title: Optical coherence tomography for three-dimensional non-invasive imaging
Authors: Ong, Bi Han.
Keywords: DRNTU::Science::Medicine::Optical instruments
Issue Date: 2011
Abstract: Optical coherence tomography (OCT) is an emerging non-invasive interferometric optical imaging technique, which demonstrates high-resolution, cross- sectional views of the subsurface microstructure of inhomogeneous samples, such as biological tissue. Its working principle is analogous to ultrasound, except that it measures the back-reflection of near-infrared light waves rather than sound waves. OCT provides tissue morphology imagery at a much higher resolution of 1 to 10 !m compared to other imaging modalities such as MRI or ultrasound. However, one of the main limitations of a conventional Time Domain OCT (TD-OCT) is the relatively long data acquisition time caused by mechanical scanning. Therefore, a Fourier Domain OCT (FD-OCT) setup was built and characterized in this paper, as it provides advantages in signal-to-noise ratio, permitting faster signal acquisition preferred for high speed three dimensional imaging. With the fundamental understanding of the theory, the developed FD-OCT setup will aid to visualize structure of interest along their contour. The system uses a broadband SLD source, increasing the performance and allowing imaging turbid samples with good image-to-noise ratio. After tuning and calibration of the instrument, the achieved axial resolution and lateral resolution are 9 μm and 11 μm respectively, and displayed an acquisition rate of 66 Hz, producing a resultant image of a 2D scan in approximately 50 seconds.
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Student Reports (FYP/IA/PA/PI)

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