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Title: Biosynthetic mechanism of antitumor enediyne natural products.
Authors: Liang, Zhao-Xun.
Keywords: DRNTU::Science::Biological sciences::Biochemistry
Issue Date: 2010
Abstract: In the past three years, we have characterized two linear carbonyl-conjugated polyenes generated by the iterative polyketide synthase (PKS) involved in the biosynthesis of the 10- membered enediyne core of calicheamicin. The results provide insight into the mysterious biosynthetic mechanism of the unique enediyne. The carbonyl-conjugated polyene differs from the precursor for 9-membered enediyne, suggesting that the divergence of the 9- and 10- membered enediyne biosynthetic pathways starts at the PKS stage.
Description: 17 p.
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Research Reports (Staff & Graduate Students)

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