Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/46700
Title: Biosynthetic mechanism of antitumor enediyne natural products.
Authors: Liang, Zhao-Xun.
Keywords: DRNTU::Science::Biological sciences::Biochemistry
Issue Date: 2010
Abstract: In the past three years, we have characterized two linear carbonyl-conjugated polyenes generated by the iterative polyketide synthase (PKS) involved in the biosynthesis of the 10- membered enediyne core of calicheamicin. The results provide insight into the mysterious biosynthetic mechanism of the unique enediyne. The carbonyl-conjugated polyene differs from the precursor for 9-membered enediyne, suggesting that the divergence of the 9- and 10- membered enediyne biosynthetic pathways starts at the PKS stage.
Description: 17 p.
URI: http://hdl.handle.net/10356/46700
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Research Reports (Staff & Graduate Students)

Files in This Item:
File Description SizeFormat 
SBS_RESEARCH_REPORTS_2.pdf
  Restricted Access
4.04 MBAdobe PDFView/Open

Page view(s) 50

656
Updated on Nov 23, 2020

Download(s) 50

13
Updated on Nov 23, 2020

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.