Fabrication of micro-needles for transdermal drug delivery.
Ng, Hui Beng.
Date of Issue2009
School of Mechanical and Aerospace Engineering
Alternative means of delivering drugs such as insulin to patients sometimes include the usage of high voltage pulsing or electrical current. However, such systems are limited by their ability to push drugs across the stratum corneum at therapeutic rates. One promising solution could be the usage of a micron scale needle, to create micropores in the skin which can allow faster diffusion of drugs with greater molecular weight or polarity into the human body. In combination with a transdermal patch, an array of micro-needles can be created to enhance the intake of drugs as well. With rapid advancement in MEMS (Micro Electro Mechanical Systems), silicon micromachining had enabled the development of such devices and result in various micro-needle designs to date. In addition, micro-needles had been fabricated with the inclusion of a fluid channel along the structure to allow controlled diffusion rates. However, the steps in fabricating such structures are often complex which lowers the process reliability and repeatability. By further proposing certain fabrication protocols and improvising on the design of micro-needles, the process can be made simpler and result in more efficient manufacturing routes.
Nanyang Technological University