dc.contributor.authorSan, Tinen_US
dc.identifier.citationSan, T. (2010). In vitro activity of chitosans in combination with antibiotics against pseudomonas aeruginosa and staphylococcus aureus. Master’s thesis, Nanyang Technological University, Singapore.
dc.description80 p.en_US
dc.description.abstractChitosan and its derivative water soluble chitosan oligosaccharide are used in a variety of applications in pharmaceutical preparations. In this study, 2 wild (ATCC 15729, PAOl) and 2 mutant strains (PT121, PT149) of Pseudomonas aeruginosa and one strain of MRSA Staphylococcus aureus (ATCC43300) are investigated for drug-drug interactions in vitro. Ten antimicrobial agents (antibiotics) are combined with different degree of deacetylated chitosans and chitosan oligosaccharide. All the chitosans exhibit synergistic activity with sulfamethoxazole against all P. aeruginosa strains. Chitosan oligosaccharide-sulfamethoxazole and high molecular weight chitosan-sulfamethoxazole combination are more effective than other chitosan preparations against S. aureus. Microscopic studies of bacteria cell membrane show evidence of the collapse of membrane integrity after treating with the combined drugs. This suggests the membrane disruption function of the chitosan and disruption of cell membrane synthesis function of sulfamethoxazole act synergistically. In conclusion, chitosan and chitosan oligosaccharide are effective against both gram-negative and gram-positive bacteria in combination with sulfamethoxazole.en_US
dc.rightsNanyang Technological Universityen_US
dc.subjectDRNTU::Engineering::Mechanical engineeringen_US
dc.titleIn vitro activity of chitosans in combination with antibiotics against pseudomonas aeruginosa and staphylococcus aureusen_US
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.contributor.supervisorLim Chu Sing
dc.contributor.supervisorMeena Kishore Sakharkaren_US
dc.description.degreeMASTER OF ENGINEERING (MAE)en_US

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