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Title: Isolation and culture of porcine smooth muscle cells on acellular porcine esophagus
Authors: Wang, Lanying.
Keywords: DRNTU::Engineering::Bioengineering
Issue Date: 2005
Abstract: Esophagus cancer has been causing high death rates in Asia. Current surgical procedures are highly stressful and often the cause of postoperative complications. Attempts to create an artificial esophagus have been made to address the need for esophagus reconstruction but none is clinically useful. Tissue engineering approach might provide potential solution for this matter. One of the promising methods in tissue engineering is to employ decellularized tissues (e.g. small intestine submucosa) as scaffolds to produce substitutes such as urinary tracts and blood vessels since these cell-free structures produce a microenvironment conducive to cell attachment, growth and reorganization. Therefore, it is believed that decellularized esophagus would be a potential solution for esophageal regeneration. The objectives of this study were (1) to isolate and harvest smooth muscle cells (SMCs) from porcine esophageal tissue and (2) to study and evaluate cell-matrix interactions of decellularized porcine esophageal matrices (DPEMs) seeded with porcine esophageal smooth muscle cells (PESMCs).
Description: 89 p.
Schools: School of Mechanical and Aerospace Engineering 
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:MAE Theses

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