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Title: Oxygen transport and cell distribution of smooth muscle construct cultured under flow
Authors: Chan, Wing Yue
Keywords: DRNTU::Engineering::Bioengineering
Issue Date: 2010
Source: Chan, W. Y. (2010). Oxygen transport and cell distribution of smooth muscle construct cultured under flow. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Internal oxygen transport is important in the development of tissue construct in vitro. A new bioreactor culture system and a mathematical model were established to investigate oxygen transport in relation to cell distribution of esophageal smooth muscle tissue construct cultured under medium flow. The bioreactor system was designed to enable in-situ oxygen profiling in the flow bioreactors to capture real-time spatial oxygen data in the growing construct; the mathematical model assuming oxygen-dependent growth kinetics was formulated using Volume Averaging Method (VAM) for the transport phenomena in the multiphasic tissue construct.
Description: 311 p.
DOI: 10.32657/10356/47201
Schools: School of Mechanical and Aerospace Engineering 
Rights: Nanyang Technological University
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Theses

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