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|Title:||Development of scaffolds for oesophageal tissue engineering||Authors:||Leong, Meng Fatt||Keywords:||DRNTU::Engineering::Bioengineering||Issue Date:||2009||Source:||Leong, M. F. (2009). Development of scaffolds for oesophageal tissue engineering. Doctoral thesis, Nanyang Technological University, Singapore.||Abstract:||Tissue engineering has emerged as a potential solution to replace diseased or defective organs. This project describes the development and characterization of a tissue engineered scaffold that is suitable for the replacement of the oesophagus. Electrospinning is chosen as the fabrication method for the scaffold. Despite the versatility of the electrospinning process in fabricating fibrous scaffold, it suffers from the severe limitation of producing scaffold with microscale pores (<5|J.m) that inhibit cell infiltration. In this project, a technique that uses ice crystals as templates to fabricate cryogenic electrospun scaffolds (CES) with large three-dimensional and interconnected pores using poly(D,L-lactide) (PLA) was developed. The pore sizes were controlled by manipulating the environment's humidity, mandrel temperature and solution flow rate.||Description:||254 p.||URI:||https://hdl.handle.net/10356/47257||DOI:||10.32657/10356/47257||Rights:||Nanyang Technological University||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||MAE Theses|
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