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Title: Studies on the inhibition of viral entry of flaviviruses
Authors: Ravikumar Rajamanonmani
Keywords: DRNTU::Science::Biological sciences::Microbiology
Issue Date: 2010
Source: Ravikumar Rajamanonmani. (2010). Studies on the inhibition of viral entry of flaviviruses. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Dengue virus serotypes 1-4 (DENV1-4) cause serious febrile illness in humans, including Dengue haemorrhagic fever (DHF) and Dengue shock syndrome (DSS). Presence of avid neutralizing antibodies during clinical illness is critical in the outcome of clinical disease and severity of manifestations. Presently there are no specific anti-flaviviral therapeutic agents or an effective vaccine available for clinical use. In the current study, the possibilities of using the DENV envelope protein domain III (Ed3), as it possesses receptor binding activity, as a possible competitor to whole virus for entry into host cell receptor was explored.
Description: 166 p.
DOI: 10.32657/10356/47444
Rights: Nanyang Technological University
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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